PTPN1

PTPN1

Identifiers Symbols PTPN1; PTP1B External IDs OMIM: 176885 MGI: 97805 HomoloGene: 2119 ChEMBL: 335 GeneCards: PTPN1 Gene EC number 3.1.3.48

Gene Ontology
Molecular function	• protein tyrosine phosphatase activity • insulin receptor binding • protein binding • zinc ion binding • enzyme binding • protein kinase binding • ephrin receptor binding
Cellular component	• early endosome • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • plasma membrane • cytoplasmic vesicle
Biological process	• blood coagulation • insulin receptor signaling pathway • regulation of signal transduction • cytokine-mediated signaling pathway • regulation of endocytosis • platelet activation • endoplasmic reticulum unfolded protein response • actin cytoskeleton reorganization • peptidyl-tyrosine dephosphorylation • negative regulation of insulin receptor signaling pathway • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 5770 19246 Ensembl ENSG00000196396 ENSMUSG00000027540 UniProt P18031 P35821 RefSeq (mRNA) NM_002827 NM_011201 RefSeq (protein) NP_002818 NP_035331 Location (UCSC) Chr 20:
49.13 – 49.2 Mb Chr 2:
167.93 – 167.98 Mb PubMed search

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes.