PTP4A3

Identifiers Symbols PTP4A3; PRL-3; PRL-R; PRL3 External IDs OMIM: 606449 MGI: 1277098 HomoloGene: 22500 ChEMBL: 4162 GeneCards: PTP4A3 Gene EC number 3.1.3.48

Gene Ontology
Molecular function	• prenylated protein tyrosine phosphatase activity
Cellular component	• early endosome • plasma membrane
Biological process	• protein amino acid dephosphorylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 11156 19245 Ensembl ENSG00000184489 ENSMUSG00000059895 UniProt O75365 Q9D658 RefSeq (mRNA) NM_007079 NM_001166388 RefSeq (protein) NP_009010 NP_001159860 Location (UCSC) Chr 8:
142.4 – 142.44 Mb Chr 15:
73.72 – 73.76 Mb PubMed search

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.