PSMB3

PSMB3

Identifiers Symbols PSMB3; HC10-II External IDs OMIM: 602176 MGI: 1347014 HomoloGene: 2089 GeneCards: PSMB3 Gene EC number 3.4.25.1

Gene Ontology
Molecular function	• threonine-type endopeptidase activity
Cellular component	• proteasome complex • nucleoplasm • cytosol • proteasome core complex
Biological process	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • M phase of mitotic cell cycle • mitotic anaphase • protein polyubiquitination • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • gene expression • viral reproduction • RNA metabolic process • mRNA metabolic process • virus-host interaction • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • small molecule metabolic process • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5691 26446 Ensembl ENSG00000108294 ENSMUSG00000069744 UniProt P49720 Q9R1P1 RefSeq (mRNA) NM_002795 NM_011971 RefSeq (protein) NP_002786 NP_036101 Location (UCSC) Chr 17:
36.91 – 36.92 Mb Chr 11:
97.7 – 97.71 Mb PubMed search

Proteasome subunit beta type-3 is a protein that in humans is encoded by the PSMB3 gene.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12.