PSMA6
| Gene Ontology | |
|---|---|
| Molecular function | • RNA binding • endopeptidase activity • threonine-type endopeptidase activity • protein binding • purine ribonucleoside triphosphate binding • NF-kappaB binding |
| Cellular component | • cytoplasmic mRNA processing body • nucleus • nucleoplasm • cytoplasm • mitochondrion • cytosol • proteasome core complex • polysome • nuclear matrix • proteasome core complex, alpha-subunit complex • myofibril • sarcomere |
| Biological process | • cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • M phase of mitotic cell cycle • mitotic anaphase • protein polyubiquitination • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • gene expression • viral reproduction • RNA metabolic process • mRNA metabolic process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • small molecule metabolic process • regulation of inflammatory response • positive regulation of NF-kappaB transcription factor activity • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • proteolysis involved in cellular protein catabolic process |
| Sources: Amigo / QuickGO | |
35.75 – 35.79 Mb
55.38 – 55.42 Mb
Proteasome subunit alpha type-6 is a protein that in humans is encoded by the PSMA6 gene.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
Read more about PSMA6: Interactions