Natural Science and Technology
- PSI (computational chemistry), software
- PSI (prion), an infectious protein in yeast
- Psi (instant messaging client), a popular XMPP client program
- Pandemic Severity Index, by the US Centers for Disease Control and Prevention
- psi (pounds per square inch), a unit of pressure
- Photosystem I, a protein complex involved in photosynthesis
- Pneumonia severity index
- Pollutant Standards Index, an air pollution measure
- Porous silicon, a material
- Program Specific Information, part of the MPEG transport stream protocol
- Protocol for Stage Illumination, a communications protocol geared towards stage lighting and effects control
- Protein Structure Initiative, a structural genomics initiative of the U.S. NIGMS
- J/ψ meson, a subatomic particle
- Water potential, denoted Ψ, in physical chemistry, the potential energy of a water solution relative to pure water
- Wave function, denoted ψ, in quantum mechanics
- 'Yaw' angle, denoted ψ in aerospace engineering, the rotation angle of a vehicle around the vertical axis with the Tait-Bryan convention
- Prediction-based Semantic Indexing, Permutation based method introduced by Sahlgren and his colleagues to encode structured medical knowledge.
- Potentially Shippable Increment, an acronym used in Scrum (development)
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