PRTC may stand for:
- PEPSU Road Transport Corporation, a Punjabi government (erstwhile PEPSU) public bus -service company
- Pondicherry Road Transport Corporation, a Pondicherry government public bus-service company
- Potomac and Rappahannock Transportation Commission, a public bus service in Prince William County, Virginia
- Puerto Rico Telephone Company, the largest telephone company in Puerto Rico previously owned by Verizon. Acquired by América Móvil
- Revolutionary Party of Central American Workers – El Salvador