Protoporphyrin IX - See Also

See Also

  • Methyl aminolevulinate
  • Protoporphyrin for other roles of protoporphyrin IX
Types of tetrapyrroles
Bilanes
(Linear)
  • Bilirubin
  • Biliverdin
  • Stercobilinogen
  • Stercobilin
  • Urobilinogen
  • Urobilin
Phytobilins
  • Phytochromobilin
Phycobilins
  • Phycoerythrobilin
  • Phycocyanobilin
  • Phycourobilin
  • Phycoviolobilin
Macrocycle
Corrinoids
  • Methylcobalamin
  • Adenosylcobalamin
  • Cyanocobalamin
Porphyrins
Protoporphyrins
  • Protoporphyrin IX
  • Heme (b, c, a, o)
  • Zinc protoporphyrin
  • Magnesium protoporphyrin
Phytoporphyrins
  • Chlorophyll c1
  • Chlorophyll c2
  • Protochlorophyllide
Reduced
porphyrins
Porphyrinogens
  • Uroporphyrinogen (I, III)
  • Coproporphyrinogen (I, III)
  • Protoporphyrinogen IX
Chlorins
  • Chlorophyllide (a, b)
  • Chlorophyll (a, b)
  • Phaeophytin (a, b)
  • Bacteriochlorophyll c
Bacteriochlorins
  • Bacteriochlorophyll a
Isobacteriochlorins
  • Siroheme
  • Sirohydrochlorin
Corphins
  • Cofactor F430
  • biochemical families: carbohydrates
    • alcohols
    • glycoproteins
    • glycosides
  • lipids
    • eicosanoids
    • fatty acids / intermediates
    • phospholipids
    • sphingolipids
    • steroids
  • nucleic acids
    • constituents / intermediates
  • proteins
    • amino acids / intermediates
  • tetrapyrroles / intermediates
Heme metabolic intermediates
Porphyrin biosynthesis

early mitochondrial: D-Aminolevulinic acid

cytosolic: Porphobilinogen · Hydroxymethylbilane · Uroporphyrinogen III · Coproporphyrinogen III

late mitochondrial: Protoporphyrinogen IX · Protoporphyrin IX
Heme degradation
and excretion
Breakdown of heme

spleen: Heme → Biliverdin → Bilirubin

blood: Bilirubin+Albumin

liver: Bilirubin diglucuronide
Intestine, excretion in feces Stercobilinogen · Stercobilin · Urobilinogen
Kidney, excretion in urine Urobilin

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns
  • biochemical families: carbohydrates
    • alcohols
    • glycoproteins
    • glycosides
  • lipids
    • eicosanoids
    • fatty acids / intermediates
    • phospholipids
    • sphingolipids
    • steroids
  • nucleic acids
    • constituents / intermediates
  • proteins
    • amino acids / intermediates
  • tetrapyrroles / intermediates

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