Protein–protein Interaction Prediction

Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions between pairs or groups of proteins. Understanding protein–protein interactions is important for the investigation of intracellular signaling pathways, modelling of protein complex structures and for gaining insights into various biochemical processes. Experimentally, physical interactions between pairs of proteins can be inferred from a variety of experimental techniques, including yeast two-hybrid systems, protein-fragment complementation assays (PCA), affinity purification/mass spectrometry, protein microarrays, fluorescence resonance energy transfer (FRET), and Microscale Thermophoresis (MST). Efforts to experimentally determine the interactome of numerous species are ongoing, and a number of computational methods for interaction prediction have been developed in recent years.

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Protein–protein Interaction Prediction - See Also
... Interactome Protein–protein interaction Macromolecular docking Protein–DNA interaction site predictor Two-hybrid screening Protein structure prediction software FastContact ...

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