Protamine Sulfate - Dosage

Dosage

Dosage for heparin reversal is 1 mg protamine sulfate i.v. for every 100 IU of active heparin. In patients who are allergic to fish, it can cause significant histamine release resulting in hypotension and bronchoconstriction; it can also cause pulmonary hypertension. Infusion should be slow to minimize these side effects. In large doses, protamine itself has some anticoagulant effect.