Chemistry
Primidone, 5-ethyl-5-phenylhexahydropyrimidine-4,6-dione is synthesized by reacting ethylphenylmalonic acid diamide with formamide.
- W.R. Boon, H.C. Carrington, C.H. Vasey, U.S. Patent 2,578,847 (1951).
- W.R. Boon, N. Greenhalgh, E. Lenden, Ch.H. Vasey, U.S. Patent 2,637,730 (1952).
An alternative method is the electrolytic reduction of phenobarbital or the catalytic reduction of the appropriate 2-thiobarbituric acid.
- Ch.H. Vasey, W. Robert, GB 666027 (1952).
Read more about this topic: Primidone
Famous quotes containing the word chemistry:
“The chemistry of dissatisfaction is as the chemistry of some marvelously potent tar. In it are the building stones of explosives, stimulants, poisons, opiates, perfumes and stenches.”
—Eric Hoffer (1902–1983)
“Science with its retorts would have put me to sleep; it was the opportunity to be ignorant that I improved. It suggested to me that there was something to be seen if one had eyes. It made a believer of me more than before. I believed that the woods were not tenantless, but choke-full of honest spirits as good as myself any day,—not an empty chamber, in which chemistry was left to work alone, but an inhabited house,—and for a few moments I enjoyed fellowship with them.”
—Henry David Thoreau (1817–1862)