Signs and Symptoms
PSC is characterized by recurrent episodes of cholangitis, with progressive biliary scarring and obstruction.
- Chronic fatigue (a non-specific symptom often present in liver disease)
- Severe jaundice with intense itching
- Malabsorption (especially of fat) and steatorrhea (fatty stool) due to biliary obstruction, leading to decreased levels of the fat-soluble vitamins, A, D, E and K.
- Signs of cirrhosis
- Hepatomegaly
- Portal hypertension
- Ascending cholangitis, or infection of the bile duct.
- Dark urine due to excess conjugated bilirubin, which is water soluble, being excreted by the kidneys
- Hepatic encephalopathy
Read more about this topic: Primary Sclerosing Cholangitis
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