Treatment
The effective treatment for PDP is currently unknown due to the lack of controlled data and is largely based on case reports. Although the HPGD enzyme is likely to be involved into the pathogenesis of PDP, no strategies against this mutation have been reported yet, since it is hard to tackle a defective enzyme. Gene therapy could be a solution for this, although this has not been reported yet in literature.
Conventional PDP drug treatment to decrease inflammation and pain includes NSAIDs and corticosteroids. Other drugs used by PDP patients target bone formation or skin manifestations. Surgical care is used to improve cosmetic appearance.
Read more about this topic: Primary Hypertrophic Osteoathropathy
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—Henry David Thoreau (1817–1862)
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—Margaret Mead (1901–1978)
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—Hippocrates (c. 460–c. 370 B.C.)