Primary Hypertrophic Osteoathropathy - Cause

Cause

Although the pathogenesis of PDP is still not fully understood, two theories have been suggested:

• The neurogenic theory proposes that stimulation of the vagus nerve leads to vasodilation, increased blood flow and PDP.
• The humoral theory proposes that mediators such as growth factors or inflammatory mediators are increased, leading to fibroblast proliferation and PDP. This theory is explained in the next sections.