PRB may refer to:
- PRB (car), the Australian Automotive Manufacturer
- PRB (vessel)
- The unofficial ISO 4217 code for the Transnistrian ruble
PRB is short for:
- Pabst Blue Ribbon, beer
- Powder River Basin, a major coal producing geologic basin in the USA
- Brazilian Republican Party, (Partido Republicano Brasileiro, in Portuguese)
- Benin Rebirth Party (Parti de la Renaissance du Bénin, in French)
- Pre-Raphaelite Brotherhood, a group of English painters, poets and critics, founded in 1848 by John Everett Millais, Dante Gabriel Rossetti and William Holman Hunt
- Population Reference Bureau
- Parti Rakyat Brunei, a now extinct political party in Brunei
- Retinoblastoma protein pRb or Rb, is a tumor suppressor protein found to be dysfunctional in a number of types of cancer
- The People's Republic of Berkeley, a common nickname for Berkeley, California
- The People's Republic of Boulder, a parallel nickname for Boulder, Colorado
- People's Republic of Bulgaria
- Physical Review B, a top journal in condensed matter physics
- Permeable Reactive Barrier, a system for groundwater remediation
- Poudreries Réunies de Belgique SA, a defunct Belgium defence manufacturer