PPM1A
Gene Ontology | |
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Molecular function | • magnesium ion binding • protein serine/threonine phosphatase activity • signal transducer activity • protein binding • manganese ion binding • calmodulin-dependent protein phosphatase activity • R-SMAD binding |
Cellular component | • nucleus • nucleoplasm • cytosol |
Biological process | • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • cell cycle arrest • transforming growth factor beta receptor signaling pathway • insulin receptor signaling pathway • gene expression • negative regulation of SMAD protein complex assembly • Wnt receptor signaling pathway • dephosphorylation • positive regulation of Wnt receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • peptidyl-threonine dephosphorylation • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of transcription, DNA-dependent |
Sources: Amigo / QuickGO |
60.71 – 60.77 Mb
72.76 – 72.79 Mb
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.
Read more about PPM1A: Interactions