Potter sequence (also known as Potter's syndrome, Potter's sequence or Oligohydramnios sequence) is the atypical physical appearance of a fetus or neonate due to oligohydramnios experienced in the womb. Oligohydramnios is the decrease in amniotic fluid volume sufficient to cause disruptions in morphogenesis of the fetus.
Oligohydramnios is the causative agent of Potter sequence, but there are many things that can lead to oligohydramnios. It can be caused by renal diseases such as bilateral renal agenesis (BRA), atresia of the ureter or urethra causing obstruction of the urinary tract, polycystic or multicystic kidney diseases, renal hypoplasia, amniotic rupture, uteroplacental insufficiency from maternal hypertension or toxemia.
Potter's sequence is known in the medical field as clubbed feet, pulmonary hypoplasia and cranial anomalies related to the oligohydramnios.
The term Potter sequence was initially intended to only refer to cases caused by BRA, however, it has been mistakenly used by many clinicians and researchers to refer to any case that presents with oligohydramnios or anhydramnios regardless of the source of the loss of amniotic fluid.
Read more about Potter Sequence: History, Types, Terminology: Syndrome Versus Sequence, Classic Form, Normal Kidney Development, Importance of Fetal Urine, Physical Characteristics, Prognosis, Genetics
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