The Signal For Activation
A number of genes required for the postreplication checkpoint encode proteins that recognize single-stranded DNA and the 5' end of transitions between single-stranded DNA and double-stranded DNA. These structure are known to be generated in two different ways during S phase. The replication of DNA containing damaged bases leaves gaps in the newly-synthesized DNA strand, and the replication of nicked or gapped DNA creates double-strand breaks. Both structures are thought to activate the postreplication checkpoint.
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“A signal is comprehended if it serves to make us notice the object or situation it bespeaks. A symbol is understood when we conceive the idea it presents.”
—Susanne K. Langer (1895–1995)