The Signal For Activation
A number of genes required for the postreplication checkpoint encode proteins that recognize single-stranded DNA and the 5' end of transitions between single-stranded DNA and double-stranded DNA. These structure are known to be generated in two different ways during S phase. The replication of DNA containing damaged bases leaves gaps in the newly-synthesized DNA strand, and the replication of nicked or gapped DNA creates double-strand breaks. Both structures are thought to activate the postreplication checkpoint.
Read more about this topic: Postreplication Checkpoint
Famous quotes containing the word signal:
“The experience of a sense of guilt for wrong-doing is necessary for the development of self-control. The guilt feelings will later serve as a warning signal which the child can produce himself when an impulse to repeat the naughty act comes over him. When the child can produce his on warning signals, independent of the actual presence of the adult, he is on the way to developing a conscience.”
—Selma H. Fraiberg (20th century)