Treatment
There is no known cure for PSSD, mostly because its etiology is still poorly understood. Possible treatment options for SSRI-induced sexual dysfunction have been reviewed theoretically.
According to a survey of psychiatrists, Wellbutrin (Bupropion) is the drug of choice for the treatment of SSRI-induced sexual dysfunction, although this is not an FDA-approved indication. Thirty-six percent of psychiatrists preferred switching patients with SSRI-induced sexual dysfunction to bupropion, and 43 percent favored the augmentation of the current medication with bupropion. A higher dose of bupropion (minimum 300 mg) may be necessary: a randomized study employing a lower dose (150 mg) failed to find a significant difference between bupropion, sexual therapy or combined treatment. Some off-label prescriptions also include pramipexole, ropinirole, yohimbine... and possibly other molecules increasing the dopamine blood levels.
The chemical cabergoline, which is an agonist of D2 receptors, which in turn decreases prolactin, has fully restored orgasm in 1/3rd of anorgasmic subjects, and partially restored orgasm in another 1/3rd of subjects.
Read more about this topic: Post-SSRI Sexual Dysfunction
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—C. John Sommerville (20th century)
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—Benjamin Harrison (1833–1901)