Pooky or Pookie may refer to:
- Pooky, a silicone pipe sealant similar to rubber cement or caulking
- Pooky (character), the teddy bear belonging to Garfield in the comic strip and cartoon
- Pookie (vehicle), a Rhodesian mine-detecting vehicle
- Pookie the Lion, a hand puppet on the Soupy Sales television show
- Pooky Night, an alternate name for Halloween in some parts of Ireland
- Pooky Quesnel, English actress, screenwriter and singer
- The Sterile Cuckoo, a 1969 film released in the UK as Pookie
- Pooky, an open source project on Sourceforge building multi-touch software
- Pookie, a character in the movie New Jack City
- Pookie, Arnold's Grandmother in "Hey Arnold!", a Nickelodeon cartoon