Pompe may refer to:
- Annelie Pompe (born 1980), an adventurer and athlete from Mölndal, Sweden
- Calliotropis pompe, a species of sea snail, a marine gastropod mollusk in the family Calliotropidae
- J. L. C. Pompe van Meerdervoort (1829–1908), a Dutch physician based in Nagasaki, Japan
- Johann Pompe (1901–1945), a Dutch pathologist
- Glycogen storage disease type II, also called Pompe disease
- Rue de la Pompe, a street in Paris, France, which was named after the pump which served water to the castle of Muette
- Rue de la Pompe (Paris Métro), a station on line 9 of the Paris Métro, named after the Rue de la Pompe