Comorbidity of Mental Disorders
For most of these disorders, in relation to polysubstance dependence, there is a vicious cycle that those with a dependence go through. First, Ingesting the drug creates a need for more,which creates a dopamine surge, which then creates pleasure. As the dopamine subsides, the pleasure adds to the emotional and physical pain and triggers stress transmitters, which in turn creates a craving, which must then be medicated, and thus the cycle begins again. However, the next time they use more of the drug will need to be used to get to the same degree of intoxication .
Read more about this topic: Polysubstance Dependence
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