Classification
| Polyp | Histologic appearance | Risk of malignancy | Picture | Syndromes |
|---|---|---|---|---|
| Hyperplastic | Serrated unbranched crypts | None | Hyperplastic polyposis syndrome | |
| Sessile serrated adenoma | Similar to hyperplastic with hyperserration, dilated/branched crypt base, prominent mucin cells at crypt base | Yes | ||
| Inflammatory | Raised mucosa/submucosa with inflammation | If dysplasia develops | Inflammatory Bowel Disease, ulcers, infections, mucosal prolapse | |
| Tubular Adenoma (Villous, Tubulovillous) | Tubular glands with elongated nuclei (at least low-grade atypia) | Yes | ||
| Traditional Serrated Adenoma | Serrated crypts, often villous architecture, with cytologic atypia, eosinophilic cells | Yes | ||
| Peutz-Jeghers Polyp | Smooth muscle bundles between nonneoplastic epithelium, "Christmas tree" appearance | No | Peutz–Jeghers syndrome | |
| Juvenile Polyp | Cystically dilated glands with expanded lamina propria | Not inherently, may develop dysplasia | Juvenile polyposis syndrome, identical polyps in Cronkhite-Canada syndrome | |
| Hamartomatous Polyp (Cowden Syndrome) | Variable; classical mildly fibrotic polyp with disorganized mucosa and splaying of muscularis mucosae; also inflammatory, juvenile, lipoma, ganglioneuroma, lymphoid | No | Cowden syndrome | |
| Inflammatory fibroid polyp | Spindle cells with concentric arrangements of spindle cells around blood vessels and inflammation rich in eosinophils | none |
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