Polycystic Kidney Disease 2
| Gene Ontology | |
|---|---|
| Molecular function | • receptor binding • voltage-gated ion channel activity • voltage-gated calcium channel activity • voltage-gated sodium channel activity • potassium channel activity • calcium ion binding • protein binding • cytoskeletal protein binding • voltage-gated cation channel activity • identical protein binding • protein homodimerization activity • actinin binding • HLH domain binding • ion channel binding • calcium-induced calcium release activity • ATPase binding |
| Cellular component | • polycystin complex • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • plasma membrane • integral to plasma membrane • cell-cell junction • cilium • microtubule basal body • basal plasma membrane • lamellipodium • motile primary cilium • nonmotile primary cilium • filamentous actin • cilium part • basal cortex • integral to cytosolic side of endoplasmic reticulum membrane • integral to lumenal side of endoplasmic reticulum membrane • mitotic spindle |
| Biological process | • branching involved in ureteric bud morphogenesis • liver development • embryonic placenta development • heart looping • detection of nodal flow • calcium ion transport • cell cycle arrest • JAK-STAT cascade • determination of left/right symmetry • heart development • negative regulation of cell proliferation • spinal cord development • neural tube development • regulation of cAMP metabolic process • positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S • cellular response to reactive oxygen species • metanephric part of ureteric bud development • sodium ion transmembrane transport • aorta development • regulation of cell proliferation • cytoplasmic sequestering of transcription factor • positive regulation of nitric oxide biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • detection of mechanical stimulus • release of sequestered calcium ion into cytosol • centrosome duplication • negative regulation of ryanodine-sensitive calcium-release channel activity • placenta blood vessel development • renal tubule morphogenesis • renal artery morphogenesis • calcium ion transmembrane transport • positive regulation of cell cycle arrest • cellular response to hydrostatic pressure • cellular response to osmotic stress • cellular response to fluid shear stress • determination of liver left/right asymmetry • metanephric mesenchyme development • mesonephric tubule development • mesonephric duct development • metanephric smooth muscle tissue development • metanephric cortex development • metanephric ascending thin limb development • metanephric cortical collecting duct development • metanephric distal tubule development • metanephric S-shaped body morphogenesis • regulation of calcium ion import • negative regulation of G1/S transition of mitotic cell cycle |
| Sources: Amigo / QuickGO | |
88.93 – 89 Mb
104.46 – 104.51 Mb
Polycystin-2 is a protein that in humans is encoded by the PKD2 gene.
This gene encodes a member of the polycystin protein family, called TRPP2, previously known as polycystin-2, PC2 or APKD2. TRPP2 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1(TRPP1) to produce cation-permeable currents. It was discovered by Stefan Somlo at Yale University.
Read more about Polycystic Kidney Disease 2: Clinical Significance, Interactions, See Also
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