Tagging For Degradation in Eukaryotes
For many non-coding RNAs, including tRNA, rRNA, snRNA, and snoRNA, polyadenylation is a way of marking the RNA for degradation, in at least yeast. This polyadenylation is done in the nucleus by the TRAMP complex, which adds a tail that is around 40 nucleotides long to the 3' end. The RNA is then degraded by the exosome. Poly(A) tails have also been found on human rRNA fragments, both the form of homopolymeric (A only) and heterpolymeric (mostly A) tails.
Read more about this topic: Polyadenylation
Famous quotes containing the words tagging and/or degradation:
“The 5307th has collapsed. From a medical viewpoint, they’re finished as a fighting unit.... I have never seen human beings in such condition. They’re drained, physically and psychologically drained. I’m not tagging them for specific ailments. I’m simply marking every man in the outfit A.O.E.—accumulation of everything.”
—Samuel Fuller, U.S. screenwriter, and Milton Sperling. Samuel Fuller. Doc (Andrew Duggan)
“I suppose one has a greater sense of intellectual degradation after an interview with a doctor than from any human experience.”
—Alice James (1848–1892)