History
Plerixafor was initially developed at the Johnson Matthey Technology Centre for potential use in the treatment of HIV because of its role in the blocking of CXCR4, a chemokine receptor which acts as a co-receptor for certain strains of HIV (along with the virus's main cellular receptor, CD4). Development of this indication was terminated because of lacking oral availability and cardiac disturbances. Further studies led to the new indication for cancer patients.
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—Newt Gingrich (b. 1943)
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—Henry David Thoreau (1817–1862)