Treatment
Because P. knowlesi takes only 24 hours to complete its erythrocytic cycle, it can result in very high parasite density quickly and may be fatal in humans. For this reason early treatment is advised. It responds well to treatment with chloroquine and primaquine. but if parasite counts are high and patients are severe, then infections should be treated as intensively as for severe falcipaum malaria.
In a clinical study of treatment where response was onserved after oral chloroquine was given for three days, and at 24 hours oral primaquine was administered for two consecutive days., it was found that this regime gave a rapid response with a median time to parasite clearance of three hours. This was more rapid that is found in Plasmodium vivax malaria where the median time to clearance is between six and seven hours.
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