The Piso family of ancient Rome was a prominent plebeian branch of the gens Calpurnia, descended from Calpus the son of Numa Pompilius. with at least 50 prominent Roman family members recognized. Members are known into the 2nd century.
Notable members:
- Gaius Calpurnius Piso (praetor 211 BC)
- Lucius Calpurnius Piso (consul 175)
- Lucius Calpurnius Piso Frugi (consul 133 BC)
- Lucius Calpurnius Piso Caesoninus (consul 112 BC)
- Gaius Calpurnius Piso (consul 111)
- Gaius Calpurnius Piso (consul 67 BC)
- Marcus Pupius Piso Frugi Calpurnianus - consul 61 BC
- Lucius Calpurnius Piso Caesoninus - consul 58 BC, father-in-law of Julius Caesar
- Lucius Calpurnius Piso (consul 27)
- Lucius Calpurnius Piso (consul 15 BC), pontifex
- Gnaeus Calpurnius Piso, consul 7 BC, was charged of being involved in the death of Germanicus
- Lucius Calpurnius Piso (consul 1 BC), augur
- Gaius Calpurnius Piso, senator, leader of the Pisonian conspiracy in AD 65.
- Lucius Calpurnius Piso Licinianus - briefly deputy emperor of Galba for five days in 69.
- Lucius Calpurnius Piso Frugi, usurper against Gallienus and Valens in 261. His existence is unclear.
- Gnaeus Calpurnius Piso (quaestor)