Science
- Protein Information Resource, a major protein information database and bioinformatics resource
- Partners in Research, a Canadian charity dedicated to bio-medical research
- Passive infrared sensor, often used to detect movement or presence by infrared emission
- PIR (gene), the gene for a human protein that is a possible transcriptional coregulator
- Polyisocyanurate, a plastic typically produced as a foam for thermal insulation
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