Pica may refer to:
- Pica (typography), in typesetting and document layout
- Pica (disorder), abnormal appetite for earth and other non-foods
- Pica (genus), a genus of magpie
- Pica Press, a publishing imprint
- OCLC PICA, a library automation company
- Pica, Chile, city in the Tarapacá Region of Chile
- Pica, Cumbria, a village in northwest England
- Píča, a geometric symbol used as a sexual reference in the Czech Republic and Slovakia
- Pica, an alternative name for the grape Merille
- DJ Pica Pica Pica (DJ 光光光), an alias used by Yamantaka Eye
- Joe Pica, pianist
PICA may refer to:
- Palestine Jewish Colonization Association, known by its Hebrew acronym as PICA
- Perth Institute of Contemporary Arts, Western Australia
- Pennsylvania Intergovernmental Cooperation Authority, a governmental agency in Philadelphia, Pennsylvania
- Pittsburgh Intergovernmental Cooperation Authority, a governmental agency in Pittsburgh, Pennsylvania
- Phenolic impregnated carbon ablator - Spacecraft heat shield material
- Portland Institute for Contemporary Art
- Posterior inferior cerebellar artery: a major blood supply to the Cerebellum
- Pre-integrated COF APM: system responsibility part for the element Columbus (ISS module)