Function
Phospholipase C performs a catalytic mechanism, generating inositol triphosphate (IP3) and diacylglycerol (DAG).
These molecules then go on to modulate the activity of downstream proteins important for cellular signaling. IP3 is soluble, and diffuses through the cytoplasm and interacts with IP3 receptors on the endoplasmic reticulum, causing the release of calcium and raising the level of intracellular calcium.
Further reading: Function of calcium in humans
DAG remains tethered to the inner leaflet of the plasma membrane due to its hydrophobic character, where it recruits protein kinase C (PKC), which becomes activated in conjunction with binding calcium ions. This results in a host of cellular responses through stimulation of calcium-sensitive proteins such as Calmodulin.
Further reading: Function of protein kinase C
| PI-PLC-Y | |||||||||
|---|---|---|---|---|---|---|---|---|---|
activated rac1 bound to its effector phospholipase c beta 2 |
|||||||||
| Identifiers | |||||||||
| Symbol | PI-PLC-Y | ||||||||
| Pfam | PF00387 | ||||||||
| Pfam clan | CL0384 | ||||||||
| InterPro | IPR001711 | ||||||||
| SMART | PLCYc | ||||||||
| PROSITE | PDOC50007 | ||||||||
| SCOP | 1qas | ||||||||
| SUPERFAMILY | 1qas | ||||||||
| OPM superfamily | 126 | ||||||||
| OPM protein | 2ptd | ||||||||
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Read more about this topic: Phosphoinositide Phospholipase C
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