Philadelphia Chromosome

Philadelphia chromosome or Philadelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t(9;22)(q34;q11). The presence of this translocation is a highly sensitive test for CML, since 95% of people with CML have this abnormality (the remainder have either a cryptic translocation that is invisible on G-banded chromosome preparations, or a variant translocation involving another chromosome or chromosomes as well as the long arm of chromosomes 9 and 22). However, the presence of the Philadelphia (Ph) chromosome is not sufficiently specific to diagnose CML, since it is also found in acute lymphoblastic leukemia (ALL, 25–30% in adult and 2–10% in pediatric cases) and occasionally in acute myelogenous leukemia (AML).

Read more about Philadelphia Chromosome:  Molecular Biology, Nomenclature, History

Other articles related to "philadelphia chromosome, chromosome, chromosomes":

Myeloproliferative Disease - Classification
... myeloproliferative diseases, which can be further categorized by the presence of the Philadelphia chromosome Philadelphia Chromosome "positive" Philadelphia Chromosome "negative" Chronic ...
Philadelphia Chromosome - History
... The Philadelphia chromosome was first discovered and described in 1960 by Peter Nowell from University of Pennsylvania School of Medicine and David Hungerford from the Fox Chase Cancer Center's ... Rowley at the University of Chicago identified the mechanism by which the Philadelphia chromosome arises as a translocation ...
Acute Lymphoblastic Leukemia - Prognosis
... the Philadelphia chromosome) that make treatment more difficult and prognoses poorer ... Cytogenetics, the study of characteristic large changes in the chromosomes of cancer cells, is an important predictor of outcome ... These include A translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, occurs in about 20% of adult and 5% in pediatric cases of ALL ...
Chromosome 22 (human) - Chromosomal Conditions
... in the structure or number of copies of chromosome 22 22q11.2 deletion syndrome Most people with 22q11.2 deletion syndrome are missing about 3 million base pairs on one copy of ... The deletion occurs near the middle of the chromosome at a location designated as q11.2 ... (Phelan-McDermid syndrome) The deletion of the distal tip of the chromosome 22 is related to moderate to severe developmental delay and mental retardation ...

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