PGI can denote:
- Protected Geographical Indication - one of the 3 protected denomination for agricultural products of the EU
- Parking guidance and information
- Glucose-6-phosphate isomerase, also known as Phosphoglucose isomerase
- The Portland Group, Inc., a software company providing compilers and programming tools
- Post Graduate Institute of Medical Education and Research, in Chandigarh
- Prostacyclin, or properly, PGI2
- Pyrotechnics Guild International
- Protected geographical indication, one of three Protected Geographical Status markings defined in European Union law to protect the names of regional foods.
- Sanjay Gandhi Post Graduate Institute of Medical Sciences in Lucknow
- PGi - Premiere Global Services Inc, a global web conferencing and conference calling company
- Chitato Airport, an Angolan airport with this IATA code.