Surnames
- Aaron Persico, an Italian rugby player
- Alphonse Persico, American mobster
- Carmine Persico, American mobster
- Daniel Pérsico, a politician
- Enrico Persico, Italian physicist
- Ignatius Persico, an Italian Cardinal
- Joseph E. Persico, author
- Lawrence T. Persico, Bishop-elect of Erie, Pennsylvania
- Salvatore Persico, the birth name of baseball player Joe Smith
- Theodore Persico, American mobster
- Theodore Persico, Jr., American mobster
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