Perlmutter is a German and Ashkenazi Jewish surname. It may refer to:
- Alvin H. Perlmutter, television producer
- Ed Perlmutter, US Congressman from Colorado
- Inbal Perlmutter, Israeli musician
- Isaac Perlmutter, American businessman and financier
- Kayla Perlmutter, Canadian actress
- Richard Perlmutter, songwriter, singer and producer
- Saul Perlmutter, Nobel laureate astrophysicist at Lawrence Berkeley National Laboratory
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