Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis - Treatment

Treatment

A possible treatment for PFAPA is a single dose of prednisone (1–2 mg per kg body mass) at the beginning of each fever episode. A single dose usually terminates the fever within several hours. However, in some children, prednisone causes the fever episodes to occur more frequently (and more regularly). Parents might then want to consider colchicine, which is used in the treatment of FMF. In several studies, adenotonsillectomy was found to completely resolve symptoms. Yet other studies had differing results, most being positive. Parents of children with PFAPA regularly report improvements after the children have had surgical treatment. Some children stop having episodes, others have a break in the cycle for a few months and then it comes back but the episodes are less intense.

Interleukin-1 inhibition appears to be effective in treating this condition.

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