PERC may refer to:
- Policy and Economic Research Council, a Durham, North Carolina-based economic policy think tank
- Pan-European Regional Council the European trade union arm of the International Trade Union Confederation
- Property and Environment Research Center, a free-market environmentalist think tank
- PowerEdge Expandable RAID Controller, a piece of Dell, Inc. computer hardware
- Palisades Emergency Residence Corporation Nonprofit Social Service Organization
- Pulmonary Embolism Rule-out Criteria, or PERC Rule is a clinical decision making tool to aid in the diagnosis of chest pain and/or dyspnea.
- PERC java virtual machine by Aonix (now Atego)
Perc may refer to:
- Tetrachloroethylene, also called perchloroethylene or perc, a chemical widely used for dry cleaning and metal-degreasing
- Slang for percocet