Other
- Pepe (film), a 1960 film directed by George Sidney
- Pepe, a 1960 song written by H. Wittstatt and D. Langdon
- Pepe Jeans, a European denim and casual wear company
- Frank Pepe Pizzeria Napoletana, a restaurant in New Haven, Connecticut
- People Empowered Preserved Earth, UK charity
- Parallel Element Processing Ensemble, a computer system
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