Pepe may refer to:
- Parallel Element Processing Ensemble, a computer system
- Pepe, a surname of Italian origin
- Pepe, a hypocorism or pet form of the masculine forename Joseph in Spanish and an alternative to José
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- Pepito (disambiguation), diminutive name for Pepe in Spanish culture
- Zé, Portuguese nickname for José
- The feminine form of this nickname is Pepa