Pharmacology
- Chemical name:
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Formula: C17H20FN3O3 Pharmacology: Pefloxacin is a fluoroquinolone antibiotic. Flouroquinolones such as pefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also possess effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter. Half life: 8.6 hours Unchanged pefloxacin and its metabolites may be identified in the urine 84 hours after the intake of the product. In elderly, in comparison with younger patients, the plasma clearance and the apparent volume of distribution are decreased approximately by 50%
- Elimination half life is 11–12 hours mainly through metabolites
- Pefloxacin is metabolized in the liver (85%-90%)
- Major route of elimination is renal – 9-16% of the drugs is eliminated unchanged. Limited excretion via bile
- Major metabolites constitute up to 84% of drugs recovered in urine
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