Pharmacokinetics
- Biotransformation:
Cytochrome P450 1A2 (CYP1A2) Hepatic metabolism is considerable. The main metabolites are demethylated pefloxacin, norfloxacin and pefloxacin N-oxide.
- There are marked changes in pharmacokinetics in patients with hepatic impairment. Careful monitoring of plasma levels together with appropriate dosage adjustment will be necessary.
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