Pedro C. Santana (born September 21, 1976 in San Pedro de Macorís, Dominican Republic) was a Major League Baseball (MLB) player in 2001 for the Detroit Tigers. He is 5'11" and weighs 160 lbs.
On July 16, 2001, Santana appeared in the only game of his MLB career. He entered the game in the eighth inning as a defensive replacement at second base and did not have a plate appearance. This puts Santana in select company with other players who appeared in a major league game but did not receive a plate appearance, such as Moonlight Graham.