Payoff may refer to:
- Bribery, an act of implying money or gift giving that alters the behavior of the recipient
- A payoff dominant equilibrium in game theory
- Payoff matrix or payoff function in a normal-form game in game theory
- Payoff set in set theory
- Payoff (film), a 1991 TV film starring Keith Carradine
- Gomez & Tavarès (AKA Payoff) a 2003 film