Pathology of Early MS and Silent MS
Current McDonald criteria usually do not allow to stablish a diagnosis for definite MS before two clinical attacks have appeared. This means that for clinical definite cases, MS condition has been present for a long time, difficulting the study of the initial stages. Therefore for studying this initial stage no clinical CDMS cases and pathological definitions are normally used. Sometimes patients with their first isolated attack (Clinically Isolated syndrome, or CIS) are used instead.
Cases of MS before the CIS are sometimes found during other neurological inspections and are referred to as subclinical MS., or sometimes Clinically silent MS. The previous reference states that clinically silent MS plaques were located in the periventricular areas. This reference also reports an estimate of the prevalence of silent MS as high as about 25%. Oligodendrocytes evolution is similar to normal MS clinical courses
Also cases after the CIS but before the confirming second attack (Preclinical MS) can be accepted to study the initial MS pathology
These studies are performed for ethiological research purposes and not for improving diagnosis.
Read more about this topic: Pathophysiology Of Multiple Sclerosis
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