Parathyroid chief cells (also called parathyroid principal cells or simply parathyroid cells) are cells in the parathyroid glands which produce parathyroid hormone.
The end result of increased secretion by the chief cells of a parathyroid gland is an increase in the serum level of Calcium. Parathyroid chief cells constitute one of the few cell types of the body that regulate intracellular calcium levels as a consequence of extracellular (or serum) changes in calcium concentration.
The calcium-sensing receptor (CaSR) is sensitive to an increase in serum calcium, and stimulates the uptake of calcium by the parathyroid chief cell. This mechanism is critically important, as it describes a physiological feed-back loop by which parathyroid hormone secretion is down-regulated in response to a restoration of serum calcium.
Famous quotes containing the words chief and/or cell:
“The chief imagination of Christendom,
Dante Alighieri, so utterly found himself
That he has made that hollow face of his
More plain to the mind’s eye than any face
But that of Christ.”
—William Butler Yeats (1865–1939)
“It is plain that there is no separate essence called courage, no cup or cell in the brain, no vessel in the heart containing drops or atoms that make or give this virtue; but it is the right or healthy state of every man, when he is free to do that which is constitutional to him to do.”
—Ralph Waldo Emerson (1803–1882)