Paramesonephric Duct - Regulation of Development

Regulation of Development

The development of the Müllerian ducts is controlled by the presence or absence of "AMH", or Anti-Müllerian hormone (also known as "MIF" for "Müllerian-inhibiting factor", or "MIH" for "Müllerian-inhibiting hormone").

Male embryogenesis The testes produce AMH and as a result the development of the Müllerian ducts is inhibited. Disturbances can lead to persistent Müllerian duct syndrome. The ducts disappear except for the vestigial vagina masculina and the appendix testis.
Female embryogenesis The absence of AMH results in the development of female reproductive organs, as noted above. Disturbance in the development may result in uterine absence (Müllerian agenesis) or uterine malformations. The ducts develop into the upper vagina, cervix, uterus and oviducts.

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