PAPI or Papi may refer to:
- Performance Application Programming Interface in Computer Science
- Point of Access for Providers of Information
- Precision Approach Path Indicator
- Papi (The L Word character), a character in Showtime's lesbian drama series The L Word played by Janina Gavankar
- Public And Private Information a proposed IEEE standard
- Pen And Paper Interviewing (PAPI) one of the more traditional interviewing techniques in statistical survey research
- David Ortiz, known as Big Papi, designated hitter for the Boston Red Sox baseball team
- Personality and Preference Inventory, a personality measure designed for the workplace
- Papı, a village in Azerbaijan
- Mr. Papi, a fictional character featured in most games by Sunflat Games
- Papi (brand), a line of men's fashion underwear
- Papi District, an administrative subdivision of Iran
- "Papi" (song), a 2011 song by Jennifer Lopez from Love?
- Daddy in Spanish or German