Palamedes could refer to:
- Palamedes (Greek mythology), the son of Nauplius in Greek mythology
- Palamedes (Arthurian legend), a Saracen Knight of the Round Table in the Arthurian legend
- Palamedes (romance), a 13th-century French Arthurian romance named after the knight
- 2456 Palamedes, an asteroid
- Palamedes (video game), a 1990 video game