Otus may refer to:
- Erol Otus (21st century), American artist
- HMS Otus, two ships in the Royal Navy
- Otus (bird), a genus of owls
- Otus (mythology), a giant in Greek mythology
- Otus of Cyllene, a hero in Greek mythology
- USS Otus (ARG-20), an internal combustion engine repair ship
- Otus the Head Cat, a weekly column in the Arkansas Democrat-Gazette by Michael Storey
- Otus, a member of a band Lordi