Chemical Synthesis
Aqueous solubility of oseltamivir in form of phosphate salt is 588 mg/ml at 25 °C (77 °F).
The current production method features a number of reaction steps, two of which involve potentially hazardous azides. A reported azide-free Roche synthesis of the drug is summarized graphically below:
Read more about this topic: Oseltamivir
Famous quotes containing the words chemical and/or synthesis:
“We do not want actions, but men; not a chemical drop of water, but rain; the spirit that sheds and showers actions, countless, endless actions.”
—Ralph Waldo Emerson (1803–1882)
“It is in this impossibility of attaining to a synthesis of the inner life and the outward that the inferiority of the biographer to the novelist lies. The biographer quite clearly sees Peel, say, seated on his bench while his opponents overwhelm him with perhaps undeserved censure. He sees him motionless, miserable, his head bent on his breast. He asks himself: “What is he thinking?” and he knows nothing.”
—Andre Maurois (1885–1967)