Osbourne is a surname, and may refer to:
- Aimee Osbourne, (born 1983), British model, daughter of Ozzy Osbourne
- Daniel 'Oz' Osbourne — fictional character in the Buffy the Vampire Slayer television series
- Denise Osbourne, fictional character from Coronation Street
- Glen Osbourne, (born 1971), American professional wrestler
- Isaiah Osbourne, English footballer
- Jack Osbourne, (born 1985), British son of Ozzy Osbourne
- Joey Osbourne, American musician
- Johnny Osbourne, Jamaican reggae and dancehall singer in the late 1970s and mid 1980s
- Kelly Osbourne, (born 1984), British singer, daughter of Ozzy Osbourne
- Lloyd Osbourne, American novelist
- Louis John Osbourne, (born 1975), British son of Ozzy Osbourne
- Nikki Osbourne, former host of Quizmania
- Ozzy Osbourne, (born 1948), British singer
- Sharon Osbourne, (born 1952), British TV personality and wife of Ozzy Osbourne